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Sadly, focused treatment into the clinical trials have acquired minimal triumph at this point, partially due to the heterogeneity and you may plasticity from GBM but also because of practical constraints(193)
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Considering the genomic complexity and you will numerous signaling paths out of GBM, an effective monotherapy will likely not to work. Ergo, to be a success, unique GBM treatment target line of physiological pathways and can include novel techniques eg electric field, widespread, or mobile-depending therapeutic steps.